A requisitely holistic information support can help us improve our business operation, but such information is hard to attain and even harder to attain in virtual organizations presenting a specific, more fluid form of business systems. Important difficulties include complexity and complicatedness, time (real and future, and their difference from the past), information requirements (realistic definition of them and meeting them), and related methodological problems. Anticipation capability may help business systems develop into anticipatory ones and develop their prevailing thinking style into the anticipatory system thinking (aimed at requisitely holistic mastering of the potential future, even a virtual one).