This research is an exploratory study of students’ approaches to studying histology and pathology. With the introduction of virtual microscopes in Health Science at Murdoch University, Australia, in 2006, it was crucial to investigate how this new technology impacted on students’ approaches to learning. The ASSIST survey was implemented at the beginning and end of the semester to identify any changes. Results indicate that, when the technology was integrated into the curriculum with appropriate learning activities, students using virtual microscopes moved more towards a strategic approach to learning but expressed a preference for a deep approach to teaching.