The purpose of this research is the exploration of the opinions and level of self-efficacy in the usage of Information Communication Technologies (ICTs) of teachers in Greek pre-schools in the learning process and administration of nurseries. By using the term “usage and utilisation of ICTs in the learning process” we mean the utilisation of the capabilities that new technologies offer in an educationally appropriate way so that the learning process yields positive results. By using the term “self-efficacy” we describe the strength of one’s belief in one’s own ability to use the capabilities he or she possess. In this way, the beliefs of the person in his or her ability to use a personal computer constitute the self-efficacy in computer usage. The research sample consists of 128 pre-school teachers that work in the prefecture of Kavala. Kavala’s prefecture is a representative example of an Education Authority since it consists of urban, suburban, and rural areas. The approach that is deemed to be the most appropriate for the exploration of such research questions is content analysis methodology and correlation analysis. The main findings of the study have shown statistically significant differences regarding the opinions and stances of the pre-school teachers for the introduction of the ICTs in the administration and the usage and utilisation of ICTs in the administration and preparation of teaching. Lastly, there were statistically significant differences between the opinions and stances of the pre-school teachers for the usage and utilisation of ICTs in the learning process. Instead, there were no statistically significant differences regarding the level of self-efficacy of the pre-school teachers in the usage and utilisation of the ICTs in the learning process. The research results could be used in the educational field as well as by Greek Ministry of Education, Research and Religious Affairs in order to take any corrective action, after the effort of Greek Ministry of Education, Research and Religious Affairs, to integrate ICT in the learning process with training courses since 2006.