One effective way of accelerating the commercialization of university innovations (inventions) is to execute a “Technological Entrepreneurship” framework that helps the execution of agreements between universities and industry for commercialization. Academics have been encouraged to commercialize their research and findings yet the level of success of commercialization of inventions (innovations) in industry is questionable. As there is no agreed commercialization framework to guide the execution of processes to support inventions moving from laboratories to the right market. The lack of capabilities of appropriate processes have undermined the turning of innovation and products into wealth. The research questions are designed to identify the constraints and hindrances of commercialization and the characteristics of successful processes built from framework based on selected case studies of incubation capabilities within universities commercialization program.