The modern technologies intend to solve significant problems and concerns related to service development, disease prediction, and resource optimization, the always shifting terrain of healthcare has seen notable changes. Covering security issues and technological innovations in the healthcare sector, this special series pays especially attention to machine learning, deep learning, and optimization algorithms. It is essential to inform the clients while protecting information from others. The findings of the studies shown in this series highlight the opportunities as well as the possible disadvantages of modern technologies in healthcare environments, so addressing a wide spectrum of healthcare issues.