Aim/Purpose.
This study aims to identify the influential factors in the application of Applied Data Science in healthcare.

Background.
The research examines the historical adoption and use of Applied Data Science in the healthcare industry, addressing the specific question: What are the factors that influence the use of Applied Data Science in healthcare throughout the history of information technology?

Methodology.
The study was conducted using a systematic literature review methodology following Kitchenham and Charters’ (2007) protocol, which includes planning, conducting, and reporting the review.

Contribution.
The study contributes to understanding key factors that shape the adoption and application of data science technologies in healthcare.

Findings.
The study used thematic analysis and identified six factors that influenced the application of Applied Data Science in healthcare: deep learning, data organization, medical or healthcare applications, techniques used, data and computing infrastructure, and language systems.

Recommendation for Practitioners.
The study recommends that the application of data science should adapt in response to advancements in technologies and computing infrastructure. It further suggests that recent developments in these areas may drive a significant transformation in the field.

Recommendation for Researchers.
The study recommends further examination of the evolution of applied data science in healthcare, especially from 1975 to 1990, when limited primary studies were available.

Impact on Society.
The results highlight the importance of technological infrastructure, advanced learning models, organized datasets, and ethical considerations for effective data science integration in healthcare.

Future Research.
Future studies should explore the timeline more, particularly in the time frame of 1975 to 1990, when a gap in the literature was found. Studies could also investigate regional differences, especially focusing on how differences in incomes and GDP affect healthcare data. Additionally, further research should expand beyond the ACM Digital Library to create a more comprehensive view of the field.